An aggregated analysis of hormonal factors and endometrial cancer risk by parity
نویسندگان
چکیده
منابع مشابه
Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome.
IMPORTANCE Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk for women with a mismatch repair gene mutation (Lynch syndrome). OBJECTIVE To investigate the association between hormonal factors and endometrial cancer risk in Lynch syndrome. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study included 1128 women with a mismatch repair...
متن کاملEndometrial cancer: hormonal factors, the perimenopausal "window of risk," and isoflavones.
Center for Women’s Health (G.E.H.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Medical and Scientific Services, Quintiles Inc. (C.L.H.), Research Triangle Park, North Carolina 27709-3979; Department of Obstetrics and Gynecology (C.L.H.), Duke University Medical Center, Durham, North Carolina 27710; and Department of Pathology (J.M.C.), Wake Forest University Schoo...
متن کاملParity and endometrial cancer risk: a meta-analysis of epidemiological studies
The association between parity and endometrial cancer risk is inconsistent from observational studies. We aimed to quantitatively assess the relationship by summarizing all relevant epidemiological studies. PubMed (MEDLINE), Embase and Scopus were searched up to February 2015 for eligible case-control studies and prospective studies. Random-effects model was used to pool risk estimations. Ten p...
متن کاملHormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis.
A "Western" lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using dat...
متن کاملHormonal interactions in endometrial cancer.
Endometrial cancer (EC) is the most frequent malignant tumor of the female genital tract. Increasing evidence suggests that at least two different types of EC exist. Type I is associated with an endocrine milieu of estrogen predominance. These tumors are of endometrioid histology and develop from endometrial hyperplasia. They have a good prognosis and are sensitive to endocrine manipulation. Ty...
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ژورنال
عنوان ژورنال: Cancer
سال: 2012
ISSN: 0008-543X
DOI: 10.1002/cncr.27909